Arterial stents: modelling drug release and restenosis
نویسندگان
چکیده
Artery walls have three layers. The inner layer is the intima; this contains the endothelium, a layer of cells directly next to the blood which play an important role in controlling vascular tone, regulating transport into the wall and inhibiting smooth muscle cell proliferation and migration (Corti and Badimon, 2002). The middle layer is the media which is the muscular part of the wall, containing smooth muscle cells, collagen and elastin. The outer layer is the adventitia which contains fibrous tissue (making it much stiffer than the media) and tethers the artery to the perivascular tissue.
منابع مشابه
Modelling intravascular delivery from drug-eluting stents with biodurable coating: investigation of anisotropic vascular drug diffusivity and arterial drug distribution.
In-stent restenosis occurs in coronary arteries after implantation of drug-eluting stents with non-uniform restenosis thickness distribution in the artery cross section. Knowledge of the spatio-temporal drug uptake in the arterial wall is useful for investigating restenosis growth but may often be very expensive/difficult to acquire experimentally. In this study, local delivery of a hydrophobic...
متن کاملOptimization of Drug Delivery by Drug-Eluting Stents
Drug-eluting stents (DES), which release anti-proliferative drugs into the arterial wall in a controlled manner, have drastically reduced the rate of in-stent restenosis and revolutionized the treatment of atherosclerosis. However, late stent thrombosis remains a safety concern in DES, mainly due to delayed healing of the endothelial wound inflicted during DES implantation. We present a framewo...
متن کاملAn advection-diffusion multi-layer porous model for stent drug delivery in coronary arteries
Arterial drug concentration distribution determines local toxicity. The safety issues dealt with Drug-Eluting Stents (DESs) reveal the needs for investigation about the effective factors contributing to fluctuations in arterial drug uptake. The current study focused on the importance of hypertension as an important and controversial risk factor among researchers on the efficacy of Heparin-Eluti...
متن کاملDrug eluting stents: managing coronary artery stenosis following PTCA.
Drug eluting stents (DES) release drugs that inhibit tissue growth in narrowed coronary arteries in an effort to prevent restenosis, a renarrowing of the artery. Several types of DES are under investigation in clinical trials; however, none are currently approved for use in Canada. Preliminary trial data are encouraging, demonstrating greater lumen diameter and reduced restenosis with DES versu...
متن کاملA decade of modelling drug release from arterial stents.
Drug-eluting stents have revolutionised the treatment of coronary artery disease. These small medical devices have attracted much interest over the past decade from biologists, clinicians, engineers and mathematicians alike. This article provides a comprehensive review of the modelling of drug release from arterial stents and the subsequent drug transport through arterial tissue, and acts as a ...
متن کامل